Molecular actions of NLR immune receptors in plants and animals.
Identifieur interne : 000110 ( Main/Exploration ); précédent : 000109; suivant : 000111Molecular actions of NLR immune receptors in plants and animals.
Auteurs : Jizong Wang [République populaire de Chine] ; Jijie Chai [République populaire de Chine, Allemagne]Source :
- Science China. Life sciences [ 1869-1889 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Conformation des protéines (MeSH), Humains (MeSH), Immunité des plantes (génétique), Immunité innée (génétique), Inflammasomes (génétique), Modèles biologiques (MeSH), Plantes (MeSH), Protéines NLR (génétique), Protéines NLR (métabolisme), Protéines végétales (génétique), Relation structure-activité (MeSH), Récepteurs immunologiques (génétique), Récepteurs immunologiques (métabolisme), Transduction du signal (MeSH).
- MESH :
- génétique : Immunité des plantes, Immunité innée, Inflammasomes, Protéines NLR, Protéines végétales, Récepteurs immunologiques.
- métabolisme : Protéines NLR, Récepteurs immunologiques.
- Animaux, Conformation des protéines, Humains, Modèles biologiques, Plantes, Relation structure-activité, Transduction du signal.
English descriptors
- KwdEn :
- Animals (MeSH), Humans (MeSH), Immunity, Innate (genetics), Inflammasomes (genetics), Models, Biological (MeSH), NLR Proteins (genetics), NLR Proteins (metabolism), Plant Immunity (genetics), Plant Proteins (genetics), Plants (MeSH), Protein Conformation (MeSH), Receptors, Immunologic (genetics), Receptors, Immunologic (metabolism), Signal Transduction (MeSH), Structure-Activity Relationship (MeSH).
- MESH :
- chemical , genetics : Inflammasomes, NLR Proteins, Plant Proteins, Receptors, Immunologic.
- genetics : Immunity, Innate, Plant Immunity.
- chemical , metabolism : NLR Proteins, Receptors, Immunologic.
- Animals, Humans, Models, Biological, Plants, Protein Conformation, Signal Transduction, Structure-Activity Relationship.
Abstract
NLRs constitute intracellular immune receptors in both plants and animals. Direct or indirect ligand recognition results in formation of oligomeric NLR complexes to mediate immune signaling. Over the past 20 years, rapid progress has been made in our understanding of NLR signaling. Structural and biochemical studies provide insight into molecular basis of autoinhibition, ligand recognition, and resistosome/inflammasome formation of several NLRs. In this review, we summarize these studies focusing on the structural aspect of NLRs. We also discuss the analogies and differences between plant and animal NLRs in their mechanisms of action and how the available knowledge may shed light on the signaling mechanisms of other NLRs.
DOI: 10.1007/s11427-019-1687-6
PubMed: 32613490
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Biology, School of Life Sciences, Tsinghua University, Beijing, 100084</wicri:regionArea><wicri:noRegion>100084</wicri:noRegion></affiliation></author><author><name sortKey="Chai, Jijie" sort="Chai, Jijie" uniqKey="Chai J" first="Jijie" last="Chai">Jijie Chai</name><affiliation wicri:level="1"><nlm:affiliation>Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China. chai@mpipz.mpg.de.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, 100084</wicri:regionArea><wicri:noRegion>100084</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Max-Planck Institute for Plant Breeding Research, Cologne, 50829, Germany. chai@mpipz.mpg.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-Planck Institute for Plant Breeding Research, Cologne, 50829</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Biochemistry, University of Cologne, Cologne, 50674, Germany. chai@mpipz.mpg.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, University of Cologne, Cologne, 50674</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author></analytic><series><title level="j">Science China. Life sciences</title><idno type="eISSN">1869-1889</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Humans (MeSH)</term><term>Immunity, Innate (genetics)</term><term>Inflammasomes (genetics)</term><term>Models, Biological (MeSH)</term><term>NLR Proteins (genetics)</term><term>NLR Proteins (metabolism)</term><term>Plant Immunity (genetics)</term><term>Plant Proteins (genetics)</term><term>Plants (MeSH)</term><term>Protein Conformation (MeSH)</term><term>Receptors, Immunologic (genetics)</term><term>Receptors, Immunologic (metabolism)</term><term>Signal Transduction (MeSH)</term><term>Structure-Activity Relationship (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Conformation des protéines (MeSH)</term><term>Humains (MeSH)</term><term>Immunité des plantes (génétique)</term><term>Immunité innée (génétique)</term><term>Inflammasomes (génétique)</term><term>Modèles biologiques (MeSH)</term><term>Plantes (MeSH)</term><term>Protéines NLR (génétique)</term><term>Protéines NLR (métabolisme)</term><term>Protéines végétales (génétique)</term><term>Relation structure-activité (MeSH)</term><term>Récepteurs immunologiques (génétique)</term><term>Récepteurs immunologiques (métabolisme)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Inflammasomes</term><term>NLR Proteins</term><term>Plant Proteins</term><term>Receptors, Immunologic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Immunity, Innate</term><term>Plant Immunity</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Immunité des plantes</term><term>Immunité innée</term><term>Inflammasomes</term><term>Protéines NLR</term><term>Protéines végétales</term><term>Récepteurs immunologiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>NLR Proteins</term><term>Receptors, Immunologic</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines NLR</term><term>Récepteurs immunologiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Models, Biological</term><term>Plants</term><term>Protein Conformation</term><term>Signal Transduction</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Conformation des protéines</term><term>Humains</term><term>Modèles biologiques</term><term>Plantes</term><term>Relation structure-activité</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">NLRs constitute intracellular immune receptors in both plants and animals. Direct or indirect ligand recognition results in formation of oligomeric NLR complexes to mediate immune signaling. Over the past 20 years, rapid progress has been made in our understanding of NLR signaling. Structural and biochemical studies provide insight into molecular basis of autoinhibition, ligand recognition, and resistosome/inflammasome formation of several NLRs. In this review, we summarize these studies focusing on the structural aspect of NLRs. We also discuss the analogies and differences between plant and animal NLRs in their mechanisms of action and how the available knowledge may shed light on the signaling mechanisms of other NLRs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32613490</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>11</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1869-1889</ISSN><JournalIssue CitedMedium="Internet"><Volume>63</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Science China. Life sciences</Title><ISOAbbreviation>Sci China Life Sci</ISOAbbreviation></Journal><ArticleTitle>Molecular actions of NLR immune receptors in plants and animals.</ArticleTitle><Pagination><MedlinePgn>1-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11427-019-1687-6</ELocationID><Abstract><AbstractText>NLRs constitute intracellular immune receptors in both plants and animals. Direct or indirect ligand recognition results in formation of oligomeric NLR complexes to mediate immune signaling. Over the past 20 years, rapid progress has been made in our understanding of NLR signaling. Structural and biochemical studies provide insight into molecular basis of autoinhibition, ligand recognition, and resistosome/inflammasome formation of several NLRs. In this review, we summarize these studies focusing on the structural aspect of NLRs. We also discuss the analogies and differences between plant and animal NLRs in their mechanisms of action and how the available knowledge may shed light on the signaling mechanisms of other NLRs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jizong</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chai</LastName><ForeName>Jijie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China. chai@mpipz.mpg.de.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Max-Planck Institute for Plant Breeding Research, Cologne, 50829, Germany. chai@mpipz.mpg.de.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Biochemistry, University of Cologne, Cologne, 50674, Germany. chai@mpipz.mpg.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Sci China Life Sci</MedlineTA><NlmUniqueID>101529880</NlmUniqueID><ISSNLinking>1674-7305</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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name="République populaire de Chine"><noRegion><name sortKey="Wang, Jizong" sort="Wang, Jizong" uniqKey="Wang J" first="Jizong" last="Wang">Jizong Wang</name></noRegion><name sortKey="Chai, Jijie" sort="Chai, Jijie" uniqKey="Chai J" first="Jijie" last="Chai">Jijie Chai</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Chai, Jijie" sort="Chai, Jijie" uniqKey="Chai J" first="Jijie" last="Chai">Jijie Chai</name></region><name sortKey="Chai, Jijie" sort="Chai, Jijie" uniqKey="Chai J" first="Jijie" last="Chai">Jijie Chai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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